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Triptorelin is a synthetic decapeptide agonist analogue of Gn RH.
It decreases LH and FSH secretion when administered long-term and thus decreases testosterone and estrogen levels.
(NASDAQ: MACK) today announced the resignation of Dr.
Integrins are transported to filopodia via a motor protein called Myosin-X, a regulator of filopodia formation.
Based on our breakthrough experiments, we discovered that myosin-X contribute to cancer cell metastases in vitro and in vivo models and that myosin-X is highly expressed in patient samples (including breast, pancreatic, colorectal, glioma and lung carcinoma) where it correlates with poor prognosis.
Gn RH agonists bind to the Gn RH receptors on pituitary gonadotropin-producing cells, causing an initial release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) and consequently a rise in testosterone levels for a few weeks.
However, sustained use of these agents causes a decrease in the production of LH and FSH, which in turn leads to a decrease in testosterone production in the testes, reducing testosterone to castrate levels or to below the castrate threshold (50 ng/d L).