In older people, research has shown that benzodiazepines increase the risks of falls and can impair cognition, mobility and driving skills.Furthermore, long-term use can make it harder for people to stop taking the drugs.The older sedative-hypnotics that have a prolonged half-life increase the risk for next-day sedation and daytime psychomotor impairment and pose an increased risk for abuse and dependence.Other complications of benzodiazepine use include tolerance, withdrawal, abuse, and rebound insomnia.Common sedatives include xylazine (Rompun), detomidine (Dormosedan) and romifidine (Sedi Vet).All of these drugs are short-acting and provide some pain relief with their sedation.“These drugs have very dangerous side effects – falls, delirium, and they have been linked to dementia,” said Fick, a Pennsylvania State University professor, who was not involved in the current study. Mark Olfson and colleagues report in JAMA Psychiatry.
Antidepressants Selective serotonin reuptake inhibitors (SSRIs) are widely regarded as the first choice in the pharmacological treatment of chronic depression.
By binding to specific subunits of GABA Benzodiazepines are on the Beer’s List of potentially inappropriate medications for older patients.
They are not recommended in the elderly because of the risk of falls; if used, they should be given at the lowest effective dose for the shortest amount of time.
S., we see a very different picture,” said Olfson, a psychiatry professor at Columbia University Medical Center in New York.
Benzodiazepines are effective for short-term treatment of anxiety and sleep problems but risky and of questionable value for long-term use, particularly in the elderly, he and his colleagues noted.